Full ClinicalTrials.gov study record by NCT id — the deep detail beyond clinical.trial-search's summary. Returns the brief + detailed description, status, phases, conditions, study design (allocation, intervention model, primary purpose, masking), enrollment, interventions, primary and secondary outcome measures (with time frames), full eligibility criteria (inclusion/exclusion text, sex, age range, healthy-volunteers, standard age groups), lead sponsor and collaborators, all facility locations (name, city, state, country), whether results are posted, and key dates. Free, public-domain (NIH NLM). Use clinical.trial-search to find an NCT id, then this for the complete protocol.
/api/clinical/study-detailPAYMENT-SIGNATURE.The study detail API is a pay-per-call clinical endpoint built for AI agents and autonomous software. Full ClinicalTrials.gov study record by NCT id — the deep detail beyond clinical.trial-search's summary.
There is no signup and no API key. An agent (or any HTTP client) hits the endpoint, receives an x402 "402 Payment Required" challenge, signs a sub-cent USDC payment on Base or Solana, and retries — the data comes back on the paid request. That makes it a drop-in study detail data source for an agent tool-use loop, an MCP host, or a backend that needs clinical data on demand without onboarding to yet another vendor portal.
| Name | Type | Description |
|---|---|---|
nctIdrequired | string | match ^NCT\d{8}$ |
# 1. Probe with no auth → 402 envelope with PaymentRequirements curl -sS 'https://2s.io/api/clinical/study-detail?nctId=example' # 2. Sign + retry with PAYMENT-SIGNATURE: curl -sS 'https://2s.io/api/clinical/study-detail?nctId=example' \ -H 'PAYMENT-SIGNATURE: <base64-json-payload>' # Or use the canonical runner (handles probe → sign → retry): # EVM_PRIVATE_KEY=0x... node --env-file=.env.local \ # --experimental-strip-types scripts/x402-pay.ts \ # 'https://2s.io/api/clinical/study-detail?nctId=example'
import { TwoS } from '@2sio/sdk'
const client = new TwoS({
privateKey: process.env.EVM_PRIVATE_KEY as `0x${string}`,
})
const result = await client.clinical.studyDetail({
"nctId": "example"
})
console.log('endpoint:', result.endpoint)
console.log('cost:', result.costUsd, 'USDC')
console.log('tx:', result.settlement?.txHash)
console.log('data:', result.data)import os
from twosio import TwoS
client = TwoS(private_key=os.environ["EVM_PRIVATE_KEY"])
result = client.clinical.study_detail(nctId="example")
print("endpoint:", result.endpoint)
print("cost:", result.cost_usd, "USDC")
print("tx:", (result.settlement or {}).get("tx_hash"))
print("data:", result.data)// 1. Add @2sio/mcp to your MCP host config (Claude Desktop example below).
// EVM_PRIVATE_KEY funds x402 payments per call.
// claude_desktop_config.json
{
"mcpServers": {
"2sio": {
"command": "npx",
"args": ["-y", "@2sio/mcp"],
"env": { "EVM_PRIVATE_KEY": "0x..." }
}
}
}
// 2. Once the server is running, agents call this tool via standard MCP:
{
"jsonrpc": "2.0",
"id": 1,
"method": "tools/call",
"params": {
"name": "clinical.study-detail",
"arguments": {
"nctId": "example"
}
}
}| Field | Type | Description |
|---|---|---|
ok | boolean | one of: true |
items | array | |
total | integer | Total matching rows upstream; null when unknown. |
source | object |
{
"ok": true,
"items": [
{
"nctId": "example",
"briefTitle": "example",
"officialTitle": "example",
"status": "example",
"studyType": "example",
"phases": [
"example"
],
"conditions": [
"example"
],
"briefSummary": "example",
"detailedDescription": "example",
"eligibility": {
"criteria": "example",
"sex": "example",
"minimumAge": "example",
"maximumAge": "example",
"healthyVolunteers": false,
"stdAges": [
"example"
]
},
"design": {
"allocation": "example",
"interventionModel": "example",
"primaryPurpose": "example",
"masking": "example"
},
"enrollmentCount": 1,
"interventions": [
{
"type": "example",
"name": "example"
}
],
"primaryOutcomes": [
{
"measure": "example",
"timeFrame": "example"
}
],
"secondaryOutcomes": [
{
"measure": "example",
"timeFrame": "example"
}
],
"leadSponsor": "example",
"collaborators": [
"example"
],
"locations": [
{
"facility": "example",
"city": "example",
"state": "example",
"country": "example"
}
],
"hasResults": false,
"startDate": "example",
"completionDate": "example",
"lastUpdatePostedDate": "example",
"url": "example"
}
],
"total": 1,
"source": {
"provider": "example",
"url": "example",
"license": "example"
}
}