FDA drug approval history from Drugs@FDA — the official record of FDA-approved drug applications. Give a drug name (brand or generic), an FDA application number (e.g. NDA021436), or a sponsor name, and get back each application with its products (brand name, active ingredients + strengths, dosage form, route, marketing status, therapeutic-equivalence code, reference-drug flag) and its full submission history (original approvals, supplements, status + status date, review priority). Free, public-domain US government data. The authoritative "is this drug FDA-approved, by whom, when, and in what formulations" record — point-in-time public records, not medical advice.
/api/medical/drug-approvalPAYMENT-SIGNATURE.The drug approval API is a pay-per-call medical endpoint built for AI agents and autonomous software. FDA drug approval history from Drugs@FDA — the official record of FDA-approved drug applications.
There is no signup and no API key. An agent (or any HTTP client) hits the endpoint, receives an x402 "402 Payment Required" challenge, signs a sub-cent USDC payment on Base or Solana, and retries — the data comes back on the paid request. That makes it a drop-in drug approval data source for an agent tool-use loop, an MCP host, or a backend that needs medical data on demand without onboarding to yet another vendor portal.
| Name | Type | Description |
|---|---|---|
drug | string | min 2 chars · max 120 chars |
applicationNumber | string | min 3 chars · max 20 chars |
sponsor | string | min 2 chars · max 120 chars |
limit | integer | min 1 · max 50 |
# 1. Probe with no auth → 402 envelope with PaymentRequirements curl -sS 'https://2s.io/api/medical/drug-approval?drug=xx&applicationNumber=xxx&sponsor=xx&limit=5' # 2. Sign + retry with PAYMENT-SIGNATURE: curl -sS 'https://2s.io/api/medical/drug-approval?drug=xx&applicationNumber=xxx&sponsor=xx&limit=5' \ -H 'PAYMENT-SIGNATURE: <base64-json-payload>' # Or use the canonical runner (handles probe → sign → retry): # EVM_PRIVATE_KEY=0x... node --env-file=.env.local \ # --experimental-strip-types scripts/x402-pay.ts \ # 'https://2s.io/api/medical/drug-approval?drug=xx&applicationNumber=xxx&sponsor=xx&limit=5'
import { TwoS } from '@2sio/sdk'
const client = new TwoS({
privateKey: process.env.EVM_PRIVATE_KEY as `0x${string}`,
})
const result = await client.medical.drugApproval({
"drug": "xx",
"applicationNumber": "xxx",
"sponsor": "xx",
"limit": 5
})
console.log('endpoint:', result.endpoint)
console.log('cost:', result.costUsd, 'USDC')
console.log('tx:', result.settlement?.txHash)
console.log('data:', result.data)import os
from twosio import TwoS
client = TwoS(private_key=os.environ["EVM_PRIVATE_KEY"])
result = client.medical.drug_approval(drug="xx", applicationNumber="xxx", sponsor="xx", limit=5)
print("endpoint:", result.endpoint)
print("cost:", result.cost_usd, "USDC")
print("tx:", (result.settlement or {}).get("tx_hash"))
print("data:", result.data)// 1. Add @2sio/mcp to your MCP host config (Claude Desktop example below).
// EVM_PRIVATE_KEY funds x402 payments per call.
// claude_desktop_config.json
{
"mcpServers": {
"2sio": {
"command": "npx",
"args": ["-y", "@2sio/mcp"],
"env": { "EVM_PRIVATE_KEY": "0x..." }
}
}
}
// 2. Once the server is running, agents call this tool via standard MCP:
{
"jsonrpc": "2.0",
"id": 1,
"method": "tools/call",
"params": {
"name": "medical.drug-approval",
"arguments": {
"drug": "xx",
"applicationNumber": "xxx",
"sponsor": "xx",
"limit": 5
}
}
}| Field | Type | Description |
|---|---|---|
query | object | |
totalCount | number | |
returned | number | |
applications | array | |
source | object |
{
"query": {
"drug": "example",
"applicationNumber": "example",
"sponsor": "example",
"limit": 1
},
"totalCount": 1,
"returned": 1,
"applications": [
{
"applicationNumber": "example",
"sponsorName": "example",
"products": [
{
"productNumber": "example",
"brandName": "example",
"activeIngredients": [
{
"name": "example",
"strength": "example"
}
],
"dosageForm": "example",
"route": "example",
"marketingStatus": "example",
"referenceDrug": "example",
"teCode": "example"
}
],
"submissions": [
{
"type": "example",
"number": "example",
"status": "example",
"statusDate": "example",
"reviewPriority": "example",
"classCode": "example"
}
],
"brandNames": [
"example"
],
"genericNames": [
"example"
],
"manufacturerNames": [
"example"
]
}
],
"source": {
"provider": "example",
"url": "example",
"license": "example"
}
}