medical.icd10

Verify and search ICD-10-CM diagnosis codes against the official US code set (FY2026, ~98k entries). Pass code (with or without the dot, e.g. E11.9 or E119) to confirm the code exists and list its more-specific child codes, or q to keyword-search code descriptions (e.g. "type 2 diabetes neuropathy"). Optional billable_only=true restricts results to codes valid for claim submission; limit caps results (1-50, default 10). Returns a verified flag, the exact match if any, and matched codes with billable status plus short and long descriptions. Data: CMS/NCHS ICD-10-CM (public domain), refreshed each US fiscal year. Use to confirm diagnosis codes are real and current before placing them in claims, prior authorizations, or clinical documents.

price
$0.0010 USDC per call
method
GET/api/medical/icd10
payment
x402 v2 · USDC on Base (EIP-3009) or Solana (SPL transfer)
auth
None. Sign the payment, retry with PAYMENT-SIGNATURE.

Overview

The ICD-10 API verifies and searches ICD-10-CM diagnosis codes against the official US code set (FY2026, ~98k entries) — built to stop agents and LLMs from inventing codes.

Pass a code (with or without the dot, e.g. E11.9 or E119) to confirm it exists and list its more-specific child codes, or pass q to keyword-search descriptions like "type 2 diabetes neuropathy". Optional billable_only restricts results to codes valid for claim submission. Responses include a verified flag, the exact match if any, and matched codes with billable status plus short and long descriptions. Data is CMS/NCHS ICD-10-CM (public domain), refreshed each US fiscal year. No API key — pay per call with x402.

Use cases

Parameters

NameTypeDescription
codestringICD-10-CM code to verify, with or without the dot (e.g. E11.9 or E119). Returns the exact match plus more-specific child codes. Provide either code or q, not both.
min 3 chars · max 9 chars · match ^[A-Za-z][0-9][0-9A-Za-z](\.?[0-9A-Za-z]{0,4})$
qstringKeyword search over official code descriptions (e.g. "type 2 diabetes neuropathy"). Every word must match. Provide either code or q, not both.
min 3 chars · max 120 chars
billable_onlybooleanWhen true, only return codes valid for claim submission (excludes category headers).
limitintegerMaximum codes returned (1-50, default 10).
min 1 · max 50

Code samples

cURLbash
# 1. Probe with no auth → 402 envelope with PaymentRequirements
curl -sS 'https://2s.io/api/medical/icd10?code=xxx&q=xxx&billable_only=false&limit=1'

# 2. Sign + retry with PAYMENT-SIGNATURE:
curl -sS 'https://2s.io/api/medical/icd10?code=xxx&q=xxx&billable_only=false&limit=1' \
  -H 'PAYMENT-SIGNATURE: <base64-json-payload>'

# Or use the canonical runner (handles probe → sign → retry):
#   EVM_PRIVATE_KEY=0x... node --env-file=.env.local \
#     --experimental-strip-types scripts/x402-pay.ts \
#     'https://2s.io/api/medical/icd10?code=xxx&q=xxx&billable_only=false&limit=1'
TypeScript / Node — @2sio/sdktypescript
import { TwoS } from '@2sio/sdk'

const client = new TwoS({
  privateKey: process.env.EVM_PRIVATE_KEY as `0x${string}`,
})

const result = await client.medical.icd10({
  "code": "xxx",
  "q": "xxx",
  "billable_only": false,
  "limit": 1
})

console.log('endpoint:', result.endpoint)
console.log('cost:', result.costUsd, 'USDC')
console.log('tx:', result.settlement?.txHash)
console.log('data:', result.data)
Python — 2siopython
import os
from twosio import TwoS

client = TwoS(private_key=os.environ["EVM_PRIVATE_KEY"])

result = client.medical.icd10(code="xxx", q="xxx", billable_only=False, limit=1)

print("endpoint:", result.endpoint)
print("cost:", result.cost_usd, "USDC")
print("tx:", (result.settlement or {}).get("tx_hash"))
print("data:", result.data)
MCP — Claude Desktop / AgentKit / any MCP hostjson
// 1. Add @2sio/mcp to your MCP host config (Claude Desktop example below).
//    EVM_PRIVATE_KEY funds x402 payments per call.

// claude_desktop_config.json
{
  "mcpServers": {
    "2sio": {
      "command": "npx",
      "args": ["-y", "@2sio/mcp"],
      "env": { "EVM_PRIVATE_KEY": "0x..." }
    }
  }
}

// 2. Once the server is running, agents call this tool via standard MCP:

{
  "jsonrpc": "2.0",
  "id": 1,
  "method": "tools/call",
  "params": {
    "name": "medical.icd10",
    "arguments": {
      "code": "xxx",
      "q": "xxx",
      "billable_only": false,
      "limit": 1
    }
  }
}

Response

FieldTypeDescription
okboolean
one of: true
itemsarray
totalintegerTotal matching rows upstream; null when unknown.
sourceobject
metaobject
Example response datajson
{
  "ok": true,
  "items": [
    {
      "code": "example",
      "codeDotted": "example",
      "billable": false,
      "shortDescription": "example",
      "longDescription": "example"
    }
  ],
  "total": 1,
  "source": {
    "provider": "example",
    "url": "example",
    "license": "example"
  },
  "meta": {
    "mode": "verify",
    "query": {
      "code": "example",
      "q": "example",
      "billableOnly": false,
      "limit": 1
    },
    "verified": false,
    "exactMatch": {
      "code": "example",
      "codeDotted": "example",
      "billable": false,
      "shortDescription": "example",
      "longDescription": "example"
    },
    "fiscalYear": 1
  }
}

FAQ

Which ICD-10 code set is this?
ICD-10-CM, the US clinical modification, FY2026 (~98k entries). Source is CMS/NCHS, public domain, refreshed each US fiscal year.
Can I search by description instead of code?
Yes. Pass q to keyword-search code descriptions (e.g. "type 2 diabetes neuropathy"); pass code to verify a specific code and list its child codes.
How do I restrict to billable codes?
Set billable_only=true to return only codes valid for claim submission. Each result also carries a billable flag.
Do I need an API key to use the icd10 API?
No. medical.icd10 is x402-native — there is no signup and no API key. Your client makes the call, receives a 402 with payment requirements, signs a USDC payment, and retries. Funds come from a wallet you control.
How much does the icd10 API cost?
$0.0010 USDC per call, charged per request. There are no monthly fees, seats, or minimums — you pay only for the calls you make.
Can I try the icd10 API for free first?
Yes. Add ?trial=1 (or the header X-2s-Trial: 1) to get a free real call per endpoint per hour, so you can verify the response shape before wiring payment.
Which networks and tokens are supported?
USDC on Base (via EIP-3009 transferWithAuthorization) or Solana (SPL transfer), using the open x402 payment protocol.
How do I call medical.icd10 from an AI agent or MCP host?
Use @2sio/sdk (TypeScript), 2sio (Python), or the @2sio/mcp server for any MCP host — each handles the probe → sign → retry loop for you. See the code samples on this page.

Discovery

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