Normalize and verify drug names against RxNorm, the canonical US drug vocabulary from the NIH. Two modes: term ("tylenol 500mg", brand or generic, typos tolerated) returns ranked RxCUI candidates with normalized names and match scores; rxcui returns the canonical concept (name, term type like IN=ingredient / SBD=branded drug / SCD=clinical drug, suppression flag) plus related concepts — active ingredients, brand names, and available dose forms. Use before writing prescriptions data, drug interactions queries, or pharmacy integrations: verify the drug exists and get its stable identifier instead of trusting model memory. Sibling: /api/medical/icd10 (diagnosis codes). Public-domain NIH data.
/api/medical/rxnormPAYMENT-SIGNATURE.The rxnorm API is a pay-per-call medical endpoint built for AI agents and autonomous software. Normalize and verify drug names against RxNorm, the canonical US drug vocabulary from the NIH.
There is no signup and no API key. An agent (or any HTTP client) hits the endpoint, receives an x402 "402 Payment Required" challenge, signs a sub-cent USDC payment on Base or Solana, and retries — the data comes back on the paid request. That makes it a drop-in rxnorm data source for an agent tool-use loop, an MCP host, or a backend that needs medical data on demand without onboarding to yet another vendor portal.
| Name | Type | Description |
|---|---|---|
term | string | Free-text drug name. Provide term or rxcui, not both. min 2 chars · max 200 chars |
rxcui | string | match ^\d{1,8}$ |
limit | integer | min 1 · max 20 |
# 1. Probe with no auth → 402 envelope with PaymentRequirements curl -sS 'https://2s.io/api/medical/rxnorm?term=xx&rxcui=12345&limit=5' # 2. Sign + retry with PAYMENT-SIGNATURE: curl -sS 'https://2s.io/api/medical/rxnorm?term=xx&rxcui=12345&limit=5' \ -H 'PAYMENT-SIGNATURE: <base64-json-payload>' # Or use the canonical runner (handles probe → sign → retry): # EVM_PRIVATE_KEY=0x... node --env-file=.env.local \ # --experimental-strip-types scripts/x402-pay.ts \ # 'https://2s.io/api/medical/rxnorm?term=xx&rxcui=12345&limit=5'
import { TwoS } from '@2sio/sdk'
const client = new TwoS({
privateKey: process.env.EVM_PRIVATE_KEY as `0x${string}`,
})
const result = await client.medical.rxnorm({
"term": "xx",
"rxcui": "12345",
"limit": 5
})
console.log('endpoint:', result.endpoint)
console.log('cost:', result.costUsd, 'USDC')
console.log('tx:', result.settlement?.txHash)
console.log('data:', result.data)import os
from twosio import TwoS
client = TwoS(private_key=os.environ["EVM_PRIVATE_KEY"])
result = client.medical.rxnorm(term="xx", rxcui="12345", limit=5)
print("endpoint:", result.endpoint)
print("cost:", result.cost_usd, "USDC")
print("tx:", (result.settlement or {}).get("tx_hash"))
print("data:", result.data)// 1. Add @2sio/mcp to your MCP host config (Claude Desktop example below).
// EVM_PRIVATE_KEY funds x402 payments per call.
// claude_desktop_config.json
{
"mcpServers": {
"2sio": {
"command": "npx",
"args": ["-y", "@2sio/mcp"],
"env": { "EVM_PRIVATE_KEY": "0x..." }
}
}
}
// 2. Once the server is running, agents call this tool via standard MCP:
{
"jsonrpc": "2.0",
"id": 1,
"method": "tools/call",
"params": {
"name": "medical.rxnorm",
"arguments": {
"term": "xx",
"rxcui": "12345",
"limit": 5
}
}
}| Field | Type | Description |
|---|---|---|
ok | boolean | one of: true |
items | array | |
total | integer | Total matching rows upstream; null when unknown. |
source | object | |
meta | object |
{
"ok": true,
"items": [
{}
],
"total": 1,
"source": {
"provider": "example",
"url": "example",
"license": "example"
},
"meta": {
"mode": "search",
"concept": {
"rxcui": "example",
"name": "example",
"synonym": "example",
"termType": "example",
"suppressed": false
},
"related": [
{
"termType": "example",
"concepts": [
{
"rxcui": "example",
"name": "example"
}
]
}
]
}
}